What Causes High Creatinine Levels?

When you found the creatinine is higher than normal in a blood test, you should pay more attention to your physical condition. Creatinine is the metabolism wastes of muscle, which should be cleaned by the kidneys, keeping in a steady level. High creatinine level is related with many factors. Now the proper causes for high creatinine are listed, patients can have a look for a prevention and treatment.

Kidney Blood Flow

When blood creatinine increases, it may indicate reduced blood flow to the kidneys with a resulting decrease in the filtration and clearance of creatinine and other substances. Reduced blood flow or low blood pressure can be a result of heart failure, artery disease or severe dehydration. Kidney filtration rate increases with body mass, and the creatinine clearance normally keeps pace with the amount of muscle mass in healthy people. When a test indicates high blood creatinine, reduced kidney blood flow can be one cause.

Kidney Damage

Functional damage to the kidneys can be due to injury or loss of the architectural units where filtration is performed -- the glomerulus. An increase in blood creatinine and reduced excretion are signs of lost kidney glomerular function -- or glomerular filtration rate. Diseases that affect the microscopic blood vessels in the glomerulus, such as diabetes, or inflammatory or autoimmune diseases of the kidney, such as lupus, can damage the delicate structures involved in kidney filtration. Some inherited conditions such as Goodpasture syndrome, response to infectious agents such as Streptococcus and damage caused by medications can also reduce kidney function.

Urinary Tract Obstruction

Another way kidney filtration may be impaired is when something obstructs urine flow from the kidney. A blockage in the urinary tract, especially the ureter, that transfers fluid from the kidney to the bladder, the bladder itself or the urethra will obstruct the flow. Conditions that may block the urinary system include kidney stones, congenital obstructions, postinjury or postsurgical scarring, poor bladder emptying, or prostatic hypertrophy that can be benign -- BPH -- or due to prostatic cancer.


All in all, high creatinine level has a close relationship with the kidney function, and if you want to know more cause and management for high creatinine, you can contact our online doctors, leave us messages or send email to kidneyhospitalabroad@hotmail.com, we will reply you within 24 hours.