Treatment of Primary Focal Segmental Glomerulosclerosis

Primary focal segmental glomerulosclerosis is showing as nephrotic syndrome including the lots of protein urine, serious edema, hypoproteinemia and hyperlipidaemia. But in this period, FSGS patients still are in the reversible period with a effective control and treatment. This article would have a introduction about the primary FSGS.

Focal and segmental glomerulosclerosis is a morphologic pattern of glomerular injury primarily directed at the glomerular visceral epithelial cell and defined by the presence of sclerosis in parts of some glomeruli by light microscopy of a renal biopsy specimen. The lesion may be found either without an identifiable cause or in response to previous glomerular injury, glomerular hypertension, or hypertrophy FSGS is distinct from focal and global glomerulosclerosis, which has a different prognosis and treatment.

Primary FSGS can present acutely with overt nephrotic syndrome characterized by hypoalbuminemia and edema. However, primary FSGS can also present insidiously with less dramatic manifestations, possibly related to the underlying histologic variant. The diagnosis of primary FSGS is confirmed by a renal biopsy that reveals the morphologic features mentioned above plus diffuse (greater than 80 percent) effacement of the foot processes by electron microscopy. In contrast, secondary FSGS most often presents as asymptomatic proteinuria without hypoalbuminemia or edema. In addition, the kidney biopsy usually reveals glomerulomegaly, focal (rather than diffuse) foot process effacement, and, sometimes, evidence of a separate kidney disease that is responsible for the development of secondary FSGS.

Renin-angiotensin-aldosterone system blockade (with angiotensin-converting enzyme [ACE] inhibitors or angiotensin receptor blockers [ARBs]) reduces proteinuria and slows progression in proteinuric kidney diseases. However, whether or not this is effective in primary FSGS is unknown.


All in all, controlling complications such as high blood pressure, protein urine and anemia is necessary to protect the kidney functions. primary focal segmental glomerulosclerosis patients should try their best to find the therapy to reverse kidney function. Now if you want to know more information about FSGS or ask for treatment suggestions, you can contact our online doctors, leave us messages or send email to kidneyhospitalabroad@hotmail.com, we will reply you within 24 hours.