Many transplanted kidneys come from donors who have died. Some come from a living family member. The kidney was the easiest organ to transplant: tissue typing was simple, the organ was relatively easy to remove and implant, live donors could be used without difficulty, and in the event of failure, kidney dialysis was available from the 1940s. Often, the new kidney will start making urine as soon as your blood starts flowing through it. But sometimes it takes a few weeks to start working.
Renal transplantation in HIV-infected patients is associated with graft and overall survival rates similar to those of HIV-negative patients, except in cases of co-infection with hepatitis C virus (HCV), according to a new study.
The study, led by Jayme E. Locke, MD, of the University of Alabama at Birmingham, is the first national study examining outcomes among the entire U.S. cohort of HIV-positive kidney transplant recipients and comparing their outcomes to appropriately matched HIV-negative controls.
The study included 510 HIV-infected renal transplant patients and 94,948 HIV-negative controls. The 5- and 10-year graft survival among the HIV-infected patients was 68.9% and 49.5%, respectively, but was highest among those who were infected only with HIV (mono-infected) but not HCV (75% and 55.9%, respectively), Dr. Locke and colleagues reported online ahead of print in the Journal of the American Society of Nephrology. Among patients co-infected with HIV and HCV, the 5- and 10-year graft survival rates were 49.9% and 25.9%, respectively.
The researchers compared the HIV group with a matched group of HIV-negative controls. Compared with the control group, the HIV-infected patients overall had significantly lower 5- and 10-year graft survival rates (69.2% vs. 75.3% and 49.8% vs. 54.4%, respectively). The 5- and 10-year graft survival rates did not differ significantly between mono-infected HIV patients and controls (75.0% vs. 75.8% and 55.9% vs. 56.0%, respectively). The 5- and 10-year survival rates were significantly worse for patients co-infected with HIV and HCV than for matched HIV-negative controls infected with HCV (52.0% vs.64.0% and 27.0% vs. 36.2%, respectively).
Patient survival rates among all HIV-infected recipients were 83.3% and 51.5% at 5 and 10 years, respectively. The rates were higher among the mono-infected HIV patients (88.7% and 63.5%, respectively) than the co-infected patients (66.3% and 29.3%).
Additionally, compared with appropriately matched HIV-negative controls, the HIV-infected patients had similar 5-year patient survival rates (83.5% and 86.2%), but significantly lower 10-year survival rates (51.6% vs. 72.1%). The 5- and 10-year patient survival rates did not differ significantly between the mono-infected HIV patients and HIV-negative/HCV-negative controls (88.7% and 89.1% and 63.5% and 77.6%). Co-infected patients, however, had significantly worse survival at 5 and 10 years compared with HIV-negative/HCV-positive controls (67.0% vs.78.6% and 29.3% vs. 56.2%, respectively).
Renal transplantation in HIV-infected patients is associated with graft and overall survival rates similar to those of HIV-negative patients, except in cases of co-infection with hepatitis C virus (HCV), according to a new study.
The study, led by Jayme E. Locke, MD, of the University of Alabama at Birmingham, is the first national study examining outcomes among the entire U.S. cohort of HIV-positive kidney transplant recipients and comparing their outcomes to appropriately matched HIV-negative controls.
The study included 510 HIV-infected renal transplant patients and 94,948 HIV-negative controls. The 5- and 10-year graft survival among the HIV-infected patients was 68.9% and 49.5%, respectively, but was highest among those who were infected only with HIV (mono-infected) but not HCV (75% and 55.9%, respectively), Dr. Locke and colleagues reported online ahead of print in the Journal of the American Society of Nephrology. Among patients co-infected with HIV and HCV, the 5- and 10-year graft survival rates were 49.9% and 25.9%, respectively.
The researchers compared the HIV group with a matched group of HIV-negative controls. Compared with the control group, the HIV-infected patients overall had significantly lower 5- and 10-year graft survival rates (69.2% vs. 75.3% and 49.8% vs. 54.4%, respectively). The 5- and 10-year graft survival rates did not differ significantly between mono-infected HIV patients and controls (75.0% vs. 75.8% and 55.9% vs. 56.0%, respectively). The 5- and 10-year survival rates were significantly worse for patients co-infected with HIV and HCV than for matched HIV-negative controls infected with HCV (52.0% vs.64.0% and 27.0% vs. 36.2%, respectively).
Patient survival rates among all HIV-infected recipients were 83.3% and 51.5% at 5 and 10 years, respectively. The rates were higher among the mono-infected HIV patients (88.7% and 63.5%, respectively) than the co-infected patients (66.3% and 29.3%).
Additionally, compared with appropriately matched HIV-negative controls, the HIV-infected patients had similar 5-year patient survival rates (83.5% and 86.2%), but significantly lower 10-year survival rates (51.6% vs. 72.1%). The 5- and 10-year patient survival rates did not differ significantly between the mono-infected HIV patients and HIV-negative/HCV-negative controls (88.7% and 89.1% and 63.5% and 77.6%). Co-infected patients, however, had significantly worse survival at 5 and 10 years compared with HIV-negative/HCV-positive controls (67.0% vs.78.6% and 29.3% vs. 56.2%, respectively).
Doc, Chukwu Madu herbal home. You are so great sir, I am cured from HIV/AIDS Virus through the help of your mighty herbs. It happened as you said, you never let me down sir I was tested HIV/aids Negative 5 days ago right here in my Country same hospital that tested me positive some months ago. I didn't accept at the first time you saved me from death Sir DR CHUKWU MADU HERBAL HOME, with your herbs.Thank you so much sir. If you are going through any of this virus or infection reach this great herbalist on his personal email:[ dr.chukwumaduherbalhome@gmail.com ] or WhatsApp him via +2347030936239. He will save you.
ReplyDeleteThanks: my name 'DUNURAI WAYAN' From CHINA
Doc, Chukwu Madu herbal home. You are so great sir, I am cured from HIV/AIDS Virus through the help of your mighty herbs. It happened as you said, you never let me down sir I was tested HIV/aids Negative 5 days ago right here in my Country same hospital that tested me positive some months ago. I didn't accept at the first time you saved me from death Sir DR CHUKWU MADU HERBAL HOME, with your herbs.Thank you so much sir. If you are going through any of this virus or infection reach this great herbalist on his personal email:[ dr.chukwumaduherbalhome@gmail.com ] or WhatsApp him via +2347030936239. He will save you.
ReplyDeleteThanks: my name 'DUNURAI WAYAN' From CHINA