End-stage renal disease is a condition in which the kidneys no longer function normally. The most common causes of ESRD in the U.S. are diabetes and high blood pressure. These conditions can affect your kidneys. Some problems you are born with, some reactions to medicines, and some injuries can also cause ESRD. They both need to fail for end-stage renal disease to develop.
Patients with renal cell carcinoma (RCC) are at lower risk of end-stage renal disease (ESRD) requiring renal replacement therapy if they undergo partial rather than radical nephrectomy, a new study suggests.
The population-based, retrospective cohort study of 11,937 RCC patients who underwent radical nephrectomy (RN) or partial nephrectomy (PN) during 1995–2010. Researchers divided subjects into an early cohort (those who had surgery from 1995–2002) and a modern cohort (those who had surgery from 2003–2010).
In the full cohort, the study revealed no significant association between type of surgery and ESRD rate, but PN was associated with a significant 52% decreased risk of chronic kidney disease (CKD).
In the modern cohort, PN recipients had a significant 56% decreased risk of ESRD requiring renal replacement therapy (RRT) compared with patients who underwent RN, after a median follow-up of 41 months, researchers led by Stanley A. Yap, MD, of the University of California Davis in Sacramento, reported online ahead of print in BJU International. In a propensity score analysis, which the investigators used to decrease bias and to control for differences between treatment groups, PN was associated with a significant 53% decreased risk of ESRD.
In the modern cohort, the RN and PN patients had a median time of progression to ESRD of 5 months and 16 months, respectively.
“Although it is well-known that RN is associated with more CKD than PN, we provide the first direct evidence that PN is associated with ESRD requiring renal replacement therapy than RN in a modern cohort of patients with RCC,” the authors concluded.
They also stated, “The distinction of a modern cohort is important, as it consists of patients that encompass a more accurate representation of current practice,” the investigators wrote. “During earlier years of the present cohort, PN had yet to gain widespread use and acceptance.”
Of the 11,937 patients in the full cohort, 9,830 (82%) and 2,107 (18%) underwent RN or PN, respectively. Overall, during the postoperative period, ESRD developed in 292 patients (2.5%). The group included 47 patients in the PN group (2.2%) compared with 245 patients in the RN group (2.5%). The mean time to progression to ESRD was 19 months and 38 months for patients in the RN and PN groups, respectively.
The early cohort included 4,297 RN patients and 360 PN patients, which had unadjusted rates of ESRD of 3.7% and 8.6%, respectively. The modern cohort included 5,484 (76%) and 1,746 (24%) patients who underwent RN and PN, respectively, and their unadjusted rates of ESRD were 1.6% and 0.9, respectively. If you have any questiosn you can send email to kidneyhospitalabroad@hotmail.com.
Patients with renal cell carcinoma (RCC) are at lower risk of end-stage renal disease (ESRD) requiring renal replacement therapy if they undergo partial rather than radical nephrectomy, a new study suggests.
The population-based, retrospective cohort study of 11,937 RCC patients who underwent radical nephrectomy (RN) or partial nephrectomy (PN) during 1995–2010. Researchers divided subjects into an early cohort (those who had surgery from 1995–2002) and a modern cohort (those who had surgery from 2003–2010).
In the full cohort, the study revealed no significant association between type of surgery and ESRD rate, but PN was associated with a significant 52% decreased risk of chronic kidney disease (CKD).
In the modern cohort, PN recipients had a significant 56% decreased risk of ESRD requiring renal replacement therapy (RRT) compared with patients who underwent RN, after a median follow-up of 41 months, researchers led by Stanley A. Yap, MD, of the University of California Davis in Sacramento, reported online ahead of print in BJU International. In a propensity score analysis, which the investigators used to decrease bias and to control for differences between treatment groups, PN was associated with a significant 53% decreased risk of ESRD.
In the modern cohort, the RN and PN patients had a median time of progression to ESRD of 5 months and 16 months, respectively.
“Although it is well-known that RN is associated with more CKD than PN, we provide the first direct evidence that PN is associated with ESRD requiring renal replacement therapy than RN in a modern cohort of patients with RCC,” the authors concluded.
They also stated, “The distinction of a modern cohort is important, as it consists of patients that encompass a more accurate representation of current practice,” the investigators wrote. “During earlier years of the present cohort, PN had yet to gain widespread use and acceptance.”
Of the 11,937 patients in the full cohort, 9,830 (82%) and 2,107 (18%) underwent RN or PN, respectively. Overall, during the postoperative period, ESRD developed in 292 patients (2.5%). The group included 47 patients in the PN group (2.2%) compared with 245 patients in the RN group (2.5%). The mean time to progression to ESRD was 19 months and 38 months for patients in the RN and PN groups, respectively.
The early cohort included 4,297 RN patients and 360 PN patients, which had unadjusted rates of ESRD of 3.7% and 8.6%, respectively. The modern cohort included 5,484 (76%) and 1,746 (24%) patients who underwent RN and PN, respectively, and their unadjusted rates of ESRD were 1.6% and 0.9, respectively. If you have any questiosn you can send email to kidneyhospitalabroad@hotmail.com.
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