The emergence of kidney failure can affect kidney function, for patients,
scientific treatment is very important. Choose a regular treatment, avoid using
the wrong medicine, a lot of drugs harm to the kidneys is large, but also lead
to a lot sicker drugs easily lead to kidney failure, then why drugs cause kidney
failure occurs.
First, the primary kidney patients, as hypovolemia, or decreased blood
pressure, the blood supply is reduced renal ischemia and hypoxia state, it has
been unable to meet the blood and oxygen needed for normal kidney work. At this
time, a large number of drugs into the kidney will increase the sensitivity of
drug toxicity, easy to aggravate ischemia, hypoxia caused by endothelial cell
damage.
Second, the kidney has a very rich capillary, a large number of drugs with
the blood flow into the kidneys, capillary endothelial cells and their larger
contact area, resulting in the glomerular capillary endothelial cell damage,
also increases the in vivo drug involvement forming antigen - antibody complexes
opportunity deposited in glomeruli.
Third, the prototype drug or its metabolites in the urine by glomerular
basement membrane after filtration, in the tubule lumen by direct toxic tubular
epithelial cells. In addition, subsequent reabsorption and re-excretion process,
and increase the role of chance in renal tubular epithelial cells and drugs.
Fourth, when the drug with the urine by glomerular filtration, where the
water in the countercurrent multiplication mechanism of action is tubular
reabsorption. Jingdong Sino-US nephropathy network of experts pointed out that
the drug concentration in the renal tubules gradually increased, especially at
higher concentrations of the renal medulla nipple area, so prone to poisoning
kidney damage.
If you still have problems, you can contact us by email:
kidneyhospitalabroad@hotmail.com.
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