Diabetic nephropathy is already one of today's society led to the death of
most diseases, mainly due to the relative lack of patient knowledge of the
disease, which leads to serious illness and even death, for this situation,
experts through three let you know about it. 1, high blood pressure.
Hypertension and diabetic nephropathy has no direct relationship, but to the
course of pre-existing hypertension or microalbuminuria period after blood
pressure can accelerate the deterioration of renal function and progression of
diabetic nephropathy, increased urinary excretion of albumin.
2, high blood sugar. Diabetic nephropathy and high blood sugar closely
related to poor glycemic control can accelerate the development of diabetic
nephropathy, good blood glucose control can significantly slow down its
development. After hyperglycemia and glycation endproducts cause an increase in
mesangial cell proliferation, extracellular matrix increased, mesangial
expansion, glomerular basement membrane thickening.
3, renal blood flow abnormalities. High blood sugar, high glomerular
perfusion, high filtration state, increased pressure across the capillary wall,
the expansion of mesangial cells, epithelial cell foot process fusion and
produce dense droplets in glomerular epithelial cells detached from the basement
membrane . Glomerular basement membrane collagen Ⅳ messenger ribonucleic acid
increased, the basement membrane thickening, and ultimately the formation of
diffuse mesangial nodular lesions occur glomerulosclerosis. In the case of
increased pressure, protein filtration increase, also deposited in the mesangial
area and glomerular basement membrane, promoting stromal proliferation, creating
a vicious cycle, and may result in nodular and diffuse glomerulosclerosis.
If you want to know more, you can contact experts in Shijiazhuang Kidney
Disease Hospital which is a professional hospital in treating kidney disease with Chinese medicines by
email: kidneyhospitalabroad@hotmail.com.
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