How Dose Diabetic Nephropathy Transform to Kidney Failure

As we all know, uremia is harmful to our health of a serious illness. And many are from uremic patients with diabetic nephropathy evolved. So in the end it is how to evolve into diabetic nephropathy uremia it?

First, the [high blood sugar]
Early in 1985 WHO study confirmed the Diabetes Research Group, DN mainly in fasting blood glucose greater than 7.8mmol / L in patients. High blood sugar is a characteristic manifestation of diabetes, a series of metabolic disorders resulting from hyperglycemia is an important factor DN happen and eventually developed into uremia. Long-term blood sugar, kidney tissue protein and glucose molecules play a role, so that the biochemical structure of these proteins and the physicochemical properties of crosslinked change, eventually produce proteinuria. Strengthen blood glucose control can delay the type 1 and type 2 diabetes and microalbuminuria occurrence and delay progression of microalbuminuria to clinical proteinuria development.

Second, the [high blood pressure]
Hypertension is an important factor in the development of DN, DN can accelerate the development of hypertension and renal dysfunction, and even uremia. For type 1 diabetes patients, most hypertension are secondary to diabetes. And type 2 diabetic patients, the hypertension often occurs before diabetes. But anyway, hypertension can in turn make diabetes worse. In diabetic stage, control of blood pressure is very important, especially for type 1 diabetes, control blood pressure in early if you can delay the development of uremia DN 10 - 20 years.

Third, genetic background
It has long been recognized, DN incidence of genetic backgrounds. The incidence and severity of DN patients of different races there are differences, but in the same race in which there is a certain incidence of familial aggregation. Clinically, we often find that some of the patient's long-term blood sugar control is better still occur in diabetic nephropathy, and some diabetic patients blood glucose control is not ideal, but not diabetic nephropathy, namely that genetic factors have a great relationship with the patient.

[Expert Tips]
Patients with diabetes are more, patients should pay more attention to diet, especially sugar more food to eat, if food conditioning properly, diabetes will develop diabetic nephropathy, and then developed into uremia uremia is caused by people death in high-risk disease, so patients with diabetes should always remind myself.


If you want to know more knowledge about kidney disease, you can you can contact us by email: kidneyhospitalabroad@hotmail.com.