How to Take Hypotensor for Patients Who Have Diabetic Nephropathy

Diabetic nephropathy is a very common and troublesome complication of diabetes, is a chronic high blood sugar as the main clinical manifestations of systemic disease, its incidence and longer duration of diabetes with increased renal vascular disease may involve, tubular and interstitial that diabetic hypoglycemic agents how to use more effective?

1Diabetic nephropathy patients oral hypoglycemic agents should be preferred Gliquidon, except after Gliquidon oral absorption of fast, mainly formed hydroxylated and methylated metabolites in the liver metabolism, 95% of metabolites through the bile through feces, less than 5% excreted by the kidneys, so little impact on the kidneys, and the daily dose range (15-200 mg), diabetic nephropathy, and I can be selected period.

2Control diet and oral hypoglycemic agents poor blood sugar control, the patient how to use antidiabetic drugs, patients should be early use of insulin, insulin diabetic nephropathy, initial dose should not be too large, it may be early, before dinner each subcutaneous regular insulin 4 Units, or early, middle and late each 4 units, later adjusted according to blood sugar.

3Large fluctuations in blood glucose in type 1 diabetic hypoglycemic agents how to use this case to use an insulin pump or insulin pen intensive insulin therapy to control blood sugar stable at a good level. When the patient azotemia, need time to adjust the insulin dose according to blood glucose monitoring results, because patients often appear azotemia poor appetite, eating less, the fact that some insulin (about 30% to 40%) by the renal metabolism, glomerular filtration after being proximal tubular cell uptake and degradation in renal tubular epithelial cells, when renal insufficiency, kidney degradation of insulin significantly reduced blood circulation half-life of insulin, thus reducing insulin requirement.

Thus, patients with diabetic nephropathy with renal insufficiency, insulin should be regular monitoring of blood glucose, timely adjustment of the dose to avoid hypoglycemia reaction. About how to use diabetic hypoglycemic agents to answer, and I hope to be helpful to the patient, the key is to choose the appropriate hypoglycemic agents according to the disease situation, if the abnormal situation, please adjust the dosage, so as not to delay the disease.


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