Tuesday, November 24, 2015

The Cause of IgA Nephropathy

IgA nephritis main causes are the following:

(1) immune disorders
The presence of IgA rheumatoid factor in 30% of iga nephritis patients, indicating the source of the non-mucosal immunoglobulin. Check in peripheral blood lymphocytes of patients found, iga nephritis patients with IgA specific helper T cells increased and IgA-specific suppressor T cells decreased, OKT4 / OKT8 ratio increases. However, this change is unclear T cell subsets are IgA reason for the increase is the result.

(2) abnormal mucosal immunity
Pathological iga nephritis suggesting basement membrane containing IgA deposition J chain, indicating that may be secreted IgA plasma cells. Some iga nephritis patients with epithelial cells containing secretory IgA intestinal or respiratory symptoms. In addition, in some iga nephritis patients were found to have anti-diet antigens (such as gliadin, bovine serum albumin) and against respiratory pathogens (such as cytomegalovirus, adenovirus, hepatitis virus) IgA antibodies. This further illustrate the intrinsic link between iga nephritis and mucosal immunity. In recent years, the use of the mucosal immune method successfully established animal model iga nephritis, but supports this theory.


Is described above for the relevant IgA nephritis cause, you are aware of this, and if you still want to know more about kidney disease, welcome to consult our doctors or you can send email: kidneyhospitalabroad@hotmail.com.

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