IgA nephritis main causes are the following:
(1) immune disorders
The presence of IgA rheumatoid factor in 30% of iga nephritis patients,
indicating the source of the non-mucosal immunoglobulin. Check in peripheral
blood lymphocytes of patients found, iga nephritis patients with IgA specific
helper T cells increased and IgA-specific suppressor T cells decreased, OKT4 /
OKT8 ratio increases. However, this change is unclear T cell subsets are IgA
reason for the increase is the result.
(2) abnormal mucosal immunity
Pathological iga nephritis suggesting basement membrane containing IgA
deposition J chain, indicating that may be secreted IgA plasma cells. Some iga
nephritis patients with epithelial cells containing secretory IgA intestinal or
respiratory symptoms. In addition, in some iga nephritis patients were found to
have anti-diet antigens (such as gliadin, bovine serum albumin) and against
respiratory pathogens (such as cytomegalovirus, adenovirus, hepatitis virus) IgA
antibodies. This further illustrate the intrinsic link between iga nephritis and
mucosal immunity. In recent years, the use of the mucosal immune method
successfully established animal model iga nephritis, but supports this
theory.
Is described above for the relevant IgA nephritis cause, you are aware of
this, and if you still want to know more about kidney disease, welcome to
consult our doctors or you can send email: kidneyhospitalabroad@hotmail.com.
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