How Dose Diabetic Nephropathy Impair Kidneys?

Although prone to diabetic nephropathy, diabetic patients with kidney disease, diabetes generally 10 to 20 years, about half of occurrence of renal insufficiency. This is due to patient diabetes is a systemic capillary lesions, mainly capillary basement membrane thickening, resulting in abnormal microcirculation, causing many abnormal organs, organs may occur in the kidney glomerular basement membrane thickening , leading to glomerulosclerosis. Glomerular sclerosis affects the glomerular filtration rate, causing a series of changes. Diabetic nephropathy has become one of the important factors affecting the prognosis of diabetes.

Usually after about five to 10 years with diabetes may have mild asymptomatic proteinuria, when this phenomenon will prompt clinical diabetic nephropathy has begun. At the beginning of proteinuria may be intermittent, after then becomes persistent. Diabetes significant proteinuria, compared with no proteinuria poor prognosis, but there are great individual differences, some patients can survive for more than 20 years, usually at least 10 years or more.

Proteinuria After several years before symptoms appear edema kidney disease, high blood pressure. In general, the longer history of diabetes, the more severe glomerular sclerosis, the more severe proteinuria. Once severe proteinuria, kidney disease can be more rapidly deteriorating. Such as the development of the patient's proteinuria worsening proteinuria greater than 3.5 grams per day, nephrotic syndrome can occur. Diabetic nephropathy nephrotic syndrome is less than 10%, if nephrotic syndrome, the prognosis poor, often die of kidney failure five years, and cardiovascular disease. Other manifestations of diabetic nephropathy syndrome and nephrotic syndrome generally the same.

Diabetic glomerulosclerosis after experiencing long-term moderate proteinuria, renal failure can occur gradually. Developed to renal failure, speed is quite inconsistent, generally after many years later to slow the development of renal failure. Once renal failure occur, the prognosis is very poor. Renal failure, renal no obvious narrowing significantly reduced proteinuria and no. Without dialysis, the patient will die of uremia.

For patients with diabetes, as long as a good control of diabetes, you can prevent, delay or reduce the incidence of diabetic nephropathy. On the basis of the diet, proper application of hypoglycemic drugs, can prevent secondary kidney damage. Diabetic nephropathy should not use corticosteroids, it is not only ineffective for proteinuria and nephrotic syndrome, and diabetes will lead to infection and makes it more difficult to control. Edema nephrotic syndrome is more serious, is available diuretics. Have high blood pressure, it is appropriate antihypertensive therapy, vascular converting enzyme inhibitor not only for hypertension but also for proteinuria and delay the occurrence of renal failure, are good, can be routinely used. Treatment of renal failure and renal failure in general the same. It should be noted that diabetes is sometimes also have primary nephrotic syndrome, then, you should use corticosteroids, otherwise, will accelerate kidney damage.

It should be noted that the occurrence of renal failure, diabetic nephropathy, the amount of insulin required to make fine adjustments. It should monitor blood sugar as drug targets, rather than using urine as indicators. Diabetic nephropathy when patients often require dialysis due atherosclerosis, coronary heart disease, retinopathy, it is not suitable for hemodialysis, peritoneal dialysis generally better, especially in severe coronary artery disease, peripheral vascular disease resulting in fistula for blood through difficulties and severe retinopathy is more appropriate.


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