Tuesday, November 10, 2015

Clinical Symptoms of Diabetic Nephropathy

Slow progress of diabetic nephropathy, kidney disease much earlier about the symptoms. Early kidney disease increases kidney glomerular filtration hyperthyroidism and microalbuminuria sustainable for many years, is not easy to be noticed, so most patients with diabetic nephropathy is significant proteinuria or significant party is aware of edema. The main clinical manifestations of this disease are as follows:

1. proteinuria of diabetic nephropathy is the first clinical manifestation, first as intermittent, and changed to sustainability. By radioimmunoassay or micro albumin in urine albumin, proteinuria may be an early diagnosis, beneficial to control the disease.

2. edema, diabetic nephropathy proteinuria and edema caused more due to this stage show has developed to the late diabetic nephropathy. GFR decreased more associated with other clinical manifestations of renal dysfunction, suggesting a poor prognosis.

3. hypertension appeared later. Multi-stage diabetic nephropathy when elevated blood pressure, diabetes may be associated with renal vascular resistance changes in the structure and function are closely related, in addition to sodium retention is one of the factors for hypertension. Hypertension can aggravate the development of kidney disease and the deterioration of renal function, and therefore control of hypertension is essential.

4. anemia in patients with diabetic nephropathy have significant azotemia, may have mild to moderate anemia. Anemia erythropoietin disorder, ineffective treatment with iron.

5. Renal dysfunction from proteinuria appears to renal dysfunction, the interval varies greatly, if diabetes is well controlled, for many years proteinuria without renal dysfunction. If the control is not good, there will be azotemia, renal insufficiency. In addition, diabetic nephropathy often associated with diabetic retinopathy.


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