What's IgA Nephropathy

In clinical IGA nephritis is a relatively common disease glomerulonephritis, mostly occurs in young people and children, often before the onset of IGA nephritis patients there will be some upper respiratory tract infection, the main symptoms of kidney glomerular IGA nephritis patients mesangial proliferation, immunofluorescence when you can find mesangial IgA deposition area. According to the survey found that most of the IGA nephritis patients on their illness is not very understanding, therefore, the Court kidney specialists to introduce what is IGA nephritis.

IGA nephritis disease characteristics:
1.recurrent gross hematuria or microscopic hematuria, accompanied by a wide range of mesangial IgA deposition, while an increase in mesangial cells, stromal proliferation, mesangial electron dense deposits.

2.IGA nephritis is not a simple type of kidney disease, but a diagnosis immunopathology name, is a group of systemic diseases, clinical hematuria glomerular nephritis disease category, 80% in 16-35 years disease, more men than women.

IGA nephritis cause
1> infection
IGA nephritis patients, a considerable portion of patients after infection occurs, such as a cold, tonsil inflammation, fever, tuberculosis, etc., appear to the naked eye or urine occult blood positive, and by repeated episodes of infection factors. Clinically, it is precisely because the majority of IGA nephritis patients body appeared abnormal symptoms of hematuria before going to medical diagnosis and treatment.

2> mesangial cells involved in the inflammatory response IGA nephritis
IGA nephritis first occurrence is actually a process of inflammation. When IGA nephritis, kidney mesangial cells in patients with inflammatory damage will be stimulated to produce large amounts of inflammatory cytokines. Also, because the surface of mesangial cells IGA nephritis patients with IgA receptors exist, therefore the amount of in vivo abnormal accumulation of IgA immune complexes with IgA receptor will combine to form a "waterfall-like inflammation amplification reaction", resulting in a large number of immune complex deposition in the patient's kidneys and eventually cause disease produce.

3> The main body of the abnormal deposition of IgA immune complexes involved in pathogenicity

Factors affecting the IGA nephritis prognosis there?
1. Effect of age on the prognosis is now in dispute stage.

2. nephritis is a family history of family factors IGA nephritis patients prognosis.

3. moderate to severe proteinuria often prompted to eventually develop renal insufficiency, the prognosis is poor. But IGA nephritis patients with nephrotic syndrome, renal histopathological changes if slight, good reaction, the prognosis is good.


4. proteinuria or nephrotic syndrome on the prognosis of mixed views. Most scholars believe that, in severe proteinuria often prompts will eventually develop renal insufficiency, the prognosis is poor.