The reason high degree of swelling in patients with nephrotic syndrome?

The reason high degree of swelling in patients with nephrotic syndrome? Nephrotic syndrome is a group of glomerular diseases clinical syndrome, is not an independent disease, proteinuria is a special disease nephrotic syndrome due to glomerular filtration membrane damage occurs. It may be primary nephrotic syndrome, may also be secondary to nephrotic syndrome. Most adults and children with primary nephrotic syndrome, the reasons of nephrotic syndrome secondary to systemic lupus erythematosus, allergic purpura, diabetes is most common.

High degree of swelling is one of the most typical clinical symptoms of nephrotic syndrome due to high degree of swelling of nephrotic syndrome patients? The main reasons are the following two aspects:

(1) plasma colloid osmotic pressure:
Exchange of body fluids inside and outside the vessel subject to the regulation of the osmotic pressure on both sides. Including crystal osmotic pressure and colloid osmotic pressure osmotic pressure, the former from the crystalline material (mainly electrolytes), its freely through the capillary wall, so little effect on the blood vessels inside and outside the exchange of body fluids; the latter mainly from protein (mainly the albumin), since it can not freely through the capillary wall, and thus is a major factor in the exchange of body fluids inside and outside the vessel. Nephrotic syndrome, due to the large number of plasma protein loss from the urine, causing hypoproteinemia, resulting in lower plasma colloid osmotic pressure, when it fell from the normal 3.3 ~ 4kPa 0.8 ~ 1.1kPa when the intravascular water to hypertonic interstitial fluid movement, and edema.

(2) Effective hypovolemia:
The relocation of plasma water to make effective hypovolemia, which leads to the following changes in the body: by the capacity to make anti-diuretic hormone receptor (ADH) increased renal tubular reabsorption of water; through the excitement of the renin - angiotensin - aldosterone system , resulting in secondary aldosteronism, renal tubular sodium reabsorption increase; natriuretic factor inhibiting the generation of renal natriuresis reduced. So the body of water and sodium retention, further exacerbating the edema.
Severe edema of the lower limbs such as nephrotic syndrome or systemic edema, protraction, will seriously affect the work and life. Get rid of nephrotic syndrome, not blindly go with the lifting of edema. The key is to repair the damaged glomerular intrinsic cells, from fundamentally eliminate edema.

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