Thursday, June 18, 2015

Diabetes treatments may help polycystic kidney disease patients

Polycystic kidney disease affects more than 1 in 1,000 Americans, causing cysts to form on the kidneys. Symptoms and complications can include high blood pressure, cysts in the liver and other organs and pain.

When PKD causes kidneys to fail-which usually happens after many years-the patient requires dialysis or kidney transplantation. About one-half of people with the most common type of PKD progress to kidney failure, also called end-stage renal disease (ESRD).

PKD can also cause cysts in the liver and problems in other organs, such as blood vessels in the brain and heart. The number of cysts as well as the complications they cause help doctors distinguish PKD from the usually harmless "simple" cysts that often form in the kidneys in later years of life.

Gattone began researching polycystic kidney disease as a scientist at the University of Kansas and continued his work in the disease after joining the IU School of Medicine in 2000. Bacallao directs the IU Health polycystic kidney disease clinic at IU Health Methodist Hospital along with his research in the disease.

Many people with autosomal dominant PKD live for several decades without developing symptoms. For this reason, autosomal dominant PKD is often called "adult polycystic kidney disease." Yet, in some cases, cysts may form earlier in life and grow quickly, causing symptoms in childhood.

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