The researchers, led by Zhihong Liu, M.D., of the Nanjing University School of Medicine in China, reported the findings online Nov. 11 in the Annals of Internal Medicine.
Liu's team randomly assigned patients with lupus nephritis to one of two groups: One received monthly infusions of cyclophosphamide, plus oral steroid medication; the other received oral steroids, along with two immune-suppressing medications -- mycophenolate mofetil and tacrolimus.
After six months, 45.9 percent of patients on the drug trio were in complete remission, and 83.5 percent had at least a partial response. In contrast, 25.6 percent of patients on cyclophosphamide were in complete remission. And 63.0 percent had at least a partial response.
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