Renal insufficiency, due to some factors causing blood flow obstruction, so
that harmful substances remain in the body and cause harm to the kidneys,
causing kidney failure, renal failure patients then how conditioning endocrine
disorder?
Metabolism and endocrine abnormalities they produce kidney failure are the
following:
1, water, electrolyte imbalance, due to the sharp decline in glomerular
filtration rate, clearance ability to reduce the occurrence of easily water and
sodium retention. Increased tissue metabolites, non-volatile acidic products
such as SO42-, PO42-, accumulate in the body, can lead to metabolic acidosis.
Oliguria reduce potassium row; a lot of tissue damage so that potassium ions
within the cell from the extracellular fluid is released, causing hyperkalemia;
acidosis and hyperkalemia contributed. Hyperkalemia ARF is one of cause of
death.
2, high catabolism, acute renal failure, the body is in stress, greater than
anabolic catabolic. A sharp decline in kidney function, toxins accumulate,
causing the whole body system symptoms of poisoning. Wherein the
gastrointestinal symptoms first appeared, making a serious decrease your daily
intake, consume more to stimulate the body's own protein and fat reserves. By
the sepsis, severe trauma-induced ARF, a high decomposition type. Catabolism is
extremely strong, a lot of muscle protein degradation, resulting in a
significant increase nitrogen retention. High catabolism more heavy kidney
failure.
3, lipid metabolism, lipid metabolism changed mainly for the total
triglycerides, increased plasma lipoprotein triglyceride levels; plasma
cholesterol, especially in high-density lipoprotein cholesterol was reduced or
normal. The reason may be related to inhibition of lipoprotein lipase,
triglyceride 甘油清 addition to impaired ability. Studies have found that patients
with ARF outer peripheral lipoprotein lipase activity and hepatic triglyceride
glycerides activity decreased to more than 50%.
4, protein, amino acid metabolism, when the ARF, changes in hormone levels or
metabolic acidosis stimulate muscle protein breakdown and amino acid metabolism
imbalance. Plasma levels of branched chain amino acids or muscle decline,
essential amino acids / decline ratio of non-essential amino acids. High state
of decomposition, there are 250g per day or more of protein degradation, the
body is in serious negative nitrogen balance. Mechanism of acute renal failure
caused by increased protein catabolism is not very clear. Animal studies suggest
that at least with the BCAA catabolism rate-limiting enzyme - branched-chain
keto acid dehydrogenase (branched-chainketoaciddehydrogenase, BCKAD) and
ATP-dependent ubiquitin - proteasome proteolytic pathway is activation.
If you still have problems about kidneys disease. You can contact us by
email: kidneyhospitalabroad@hotmail.com.
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