Drugs Can Increase Creatinine Level

With the kidney function decline, creatinine, the metabolism wastes of muscle which are supposed to be cleaned by the kidneys, would be higher than normal, so creatnine often are as the kidney function indictor. Do you know that drugs also can lead to high creatinine level. Why, let us have a study.
In fact, there are some medicine that are toxic to the kidney tissues, so without a good control the taking medicine times and dosages, kidneys can be damaged by the medicine, leading to kidney function decline, then what kinds of drugs are bad for kidneys?

1. Antibiotics

Antibiotic is a common use drugs. It is mainly using to treat and prevent all kinds of infection. But some antibiotics, such as Aminoglycosides, Cephalosporin, Polymyxin and Amphotericin B, can lead to kidney function damage and creatinine level increase.

2. Angiotensin Converting Enzyme Inhibitors (ACE)

ACE inhibitor is a kind of drugs for patients to lower down the blood pressure. And it is the first choice for patients with kidney problem to control high blood pressure. But some patients with impaired kidney function, such as narrowing of the arterial vessels in the kidneys, should not take ACE Inhibitors because they can further damage the kidneys and raise creatinine levels.

3. Diuretics

Diuretic is a common clinical drugs to relieve the edema. But long-term use of diuretics can cause the kidney's to work overtime trying to compensate and the result is an increase in sodium reabsorption which can further lead to increase creatinine levels.

4. Chemotherapy Drugs

Several chemotherapy drugs like Cisplatin, Carbplatin, Carmustine, Mitomycin and Methotrexate may cause kidney damage and produce creatinine levels increase. Patients receiving these drugs must have labs drawn prior to administration to check their creatinine levels to make sure that their kidneys can handle the drugs.

5. NSAIDS (non-steroidal anti-inflammatory Drugs)

Non-steroid anti-inflammatory drugs, such as acetylsalicylic acid, ibuprofen, butazodine, diclofenac and indometacin and piroxicam usp and so on, have the side-effects, such as kidney failure. So it is also considered as the drugs that can lead to creatinine level increase.


Now, you must have a clear idea about the improper drugs for kidneys, so people should pay more attention to the medicine use under the suggestions of doctors. Now if you want to know more information about the high creatinine level cause and treatment, you can contact our online doctors, leave us messages or send email to kidneyhospitalabroad@hotmail.com, we will reply you within 24 hours.