Cause of Diabetic Nephroapthy

1, genetic factors. Some long-term good glycemic control in patients with diabetic nephropathy appear equally. Glucose transporter protein is the major glucose transporter mesangial cells. Recent studies have found that patients with diabetes between different individuals mesangial cells and the difference regulation of GLUT1 menu on one of the factors may be susceptible to kidney damage in some patients. And diabetic nephropathy also exhibit family aggregation, family history of hypertension in some patients with diabetes, the incidence of diabetic nephropathy was significantly higher than in patients with no family history of hypertension.

2, high blood pressure. And diabetic nephropathy has no direct relationship, but the course of pre-existing hypertension or microalbuminuria to elevated blood pressure can accelerate the deterioration of renal function and progression of diabetic nephropathy, increased urinary excretion of albumin.

3, hyperglycemia. Diabetic nephropathy and high blood sugar closely related to poor glycemic control can accelerate the development of diabetic nephropathy, good blood glucose control can significantly slow down its development. After hyperglycemia and glycation endproducts cause an increase in mesangial cell proliferation, extracellular matrix increased, mesangial expansion, glomerular basement membrane thickening.

4, renal hemodynamic abnormalities. In diabetic nephropathy, and play a key role, and may even be the initial factor.
(1) high blood sugar, high glomerular perfusion, high filtration state, increased pressure across the capillary wall, the expansion of mesangial cells, epithelial cell foot process fusion and produce dense droplets, glomerular epithelial cells from the basal film off.
(2) glomerular basement membrane collagen Ⅳ messenger ribonucleic acid increased, the basement membrane thickening, and ultimately the formation of diffuse mesangial nodular lesions occur glomerulosclerosis.
(3) In the case of increased pressure, protein filtration increase, also deposited in the mesangial area and glomerular basement membrane, promoting stromal proliferation, creating a vicious cycle, and may result in nodular and diffuse glomerulosclerosis.

We should now understand induced diabetic nephropathy What are the reasons of it, life must pay attention to high blood pressure, high blood sugar disease, do not let these diseases induce more complications, and thus to bring their own health more harm. Friends recommend regular check-ups, early detection of patients body, the first time to take effective treatment measures.


The experts in Shijiazhuang Kidney Disease Hospital which is a professional hospital in treating kidney disease with Chinese medicines can reply your questions by email: kidneyhospitalabroad@hotmail.com.