PKD Patients Suffer form the Muscle Cramp after the Dialysis

Some PKD patients are suggested to do the dialysis by doctors. While they find that they always suffer from the dialysis after the dialysis. So they want to find an effective therapy to deal with this condition.

Muscle wasting, also termed protein-energy wasting (PEW), is a state of metabolic and nutritional derangements that is closely associated with high morbidity and mortality in CKD patients. Present in 20%-50% of maintenance dialysis patients, muscle wasting can have multiple etiologies, including insufficient intake of dietary nutrients, excessive catabolism due to dialysis, metabolic acidosis, chronic inflammation, and hormonal derangements (Kidney Int. 1996;50:343-357 and Kidney Int. 2008;73:391-398) (see figure 1). Because the presence and severity of muscle wasting has a high association with mortality risk in maintenance dialysis patients, prevention and treatment of this unfavorable condition is of upmost importance. The multifactorial origin of muscle wasting renders this task especially challenging.

Total body-protein content is considered to be the most physiologically relevant nutritional parameter and an important determinant of PEW. Accordingly, a cluster of approaches referred to as anabolic interventions are focused on improving PEW through enhancing protein synthesis, decreasing protein catabolism, or a combination thereof, to maximize total body-protein stores. In this review, we will discuss the rationale and efficacy of using selected agents, nutritional supplementation, and exercise as anabolic interventions to enhance total body-protein content for the maintenance dialysis patient who has PEW or is at risk of having it, with a specific emphasis on recent advancements in this area.

Possible causes

The mechanisms leading to muscle wasting in dialysis patients are still being elucidated; they cannot be attributed to any single factor. Nevertheless, a common pathway for all the metabolic derangements leading to muscle wasting appears related to exaggerated protein degradation and, to a degree, to decreased protein synthesis.

Dietary nutrient intake. The observation that CKD patients decrease their protein and energy intake as they progressively lose kidney function has led some to conclude that uremia per se causes protein catabolism stimulated by decreased nutrient intake. This conclusion has been challenged to a certain extent because even in patients with advanced CKD, nitrogen balance studies show a concomitant decrease in both protein synthesis and degradation. However, accelerated protein degradation stimulated by acute illnesses or stress conditions could lead to excessive and uncompensated loss of protein stores.


It is not difficult for us to deal with the muscle cramps after the dialysis for PKD patients. the micro-chinese medicine osmotherapy is a good therapy in our hospital, if you want to know more information about them, you can send emails to kidneyhospitalabroad@hotmail.com, or add my whatsapp +86 13383015760.