High Creatinine in PKD

If the kidneys start to become diseased for whatever reason, the level of creatinine rises in the blood stream. What are the reasons of high creatinine for Polycystic Kidney Disease? They are as follows:

●Because the cysts in the kidney extends continuously, and then oppresses the ambient kidney tissues, which leads to the damage of kidney unit, the kidney volume outdistances the normal range in the late stage for PKD patients and no normal kidney unit can be seen in the microscope checking.

●After Polycystic Kidney Disease patients get sick for a long time, the fluctuation and increasing of creatinine will arise in the clinical checking, even the blood creatinine level exceeds the normal range, from this we know PKD develops to renal insufficiency or uremia. That blood creatinine level exceeds normal range and urine creatinine level is subnormal are the main symptoms.

●After the kidney is violated by cysts in the kidney, firstly the damaged kidney inherent cells can come up the phenotype transformation, form the pathology change, stimulate the fibroblasts in kidney to transform into myofibroblast, and at the same time violate and arouse the inherent normal kidney tissues to occur the same lesion, which leads to the kidney's spreading process of extending and excitation type from the part to the whole. Because kidney is damaged continuously, the function of excreting rubbish will lower, which leads to the gather of cretinine and other toxins in the body , the rising of blood cretinine and urea nitrogen, and the declining of urine cretinine and filterability. Meanwhile the patients can also have hypertension and severe edema .

From the above reasons, we can get that if we want to control and cure polycystic kidney, shrinking the cysts and repairing the damaged inherent cells is no time to delay.