Because of the effects of the glomerulus menbrane filtration and the renal
tubular reabsorption,the protein(almost means the smaller molecular weight
protein) content in healthy people’ urine is very little(excrete volume is less
than 150mg every day),the protein qualitative check is negative reaction.When
the protein content in the urine goes up,the ordinary urine routine test will
check out proteins,and this is called proteinuria.If the protein content is
equal or greater than 3.5g/24h,it is called heave proteinuria.
Proteinuria is a representative symptom of chronic kidney disease,the reasons
for the formation of proteinuria are intimate on the glomerular barrier
functions.Glomerular capillary is made up with three structures,
inside-to-outside,there are endodermis cell layer,base film layer and epithelial
layer.The three cell layers distribute unequal size filtration pores and
negative charges,so the glomerular barrier function can be divided into two
kinds: mechanical barrier ---filtration pores and electrostatic
barrier----negative charges.
When the kidney is pathology,a series of changes will happen to the
glomerular basement membrane(GBM):its filtration pores enlarging or closing、GMB
fracturing,electrostatic barrier injuring,kidney permeability
enhancing,negatively charged glycoprotein reducing or disappearing in filtration
membrane,all of these will cause the negatively charged plasma proteins’
filtration rate to increase more obviously than it is as usual.So,at this moment
it forms proteinuria clinically.
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Showing posts with label proteinuria. Show all posts
Showing posts with label proteinuria. Show all posts
Friday, August 21, 2015
Tuesday, March 19, 2013
Why Is There A Lot of Proteinuria For Nephrotic Syndrome
As we all know, proteinuria is a very common symptom of nephrotic syndrome,
but how many people are there know the reason why lots of proteinuria
exists.
Water and solute in blood enter renal capsule via glomerulus to become initial urine, this process must through the endothelial cells , basement membrane of capillary wall and epithelial cells. These three layer structures are called the glomerular filtration membrane. All of the three filtration membranes have certain holes, which only allows the materials that have certain molecular weight and molecular diameter to pass, so they are the size barrier of filtration membranes. The surfaces of three layer structures are covered by silaoprotein, and glomerular basement membrane inside and outside loose layer have rich heparan sulfate, these substances take negative charge in fluid environment, so they reject the solutes that take negative charge to pass, then the charge barrier of filtration membranes forms.
In addition, the intraglomerular mesangium which lies among glomerular capillaries has a regulating action to filtration barrier of glomerulus, so also has a certain effect to the filtration of glomerulus. Under the normal circumstances, most of the protein in blood can not go through the filtration barrier of glomerulus, especially the macromolecules and the albumins that take negative charge almost completely can not go through, a small amount of small molecule proteins which had gotten through filtration can be reabsorbed by kidney tubules, so protein expelled from urine is less than 150mg.
At the time of nephrotic syndrome, barrier function of filtration membrane is destroyed by a variety of pathogenic factors, the holes become bigger and negative charge decreases, which leads to the leakage of a large amount of protein, it outdistance the ability of reabsorption of kidney tubules, so a great quantity of proteinuria appears.
For nephrotic syndrome patients, they also have hypoalbuminemia because of the loss of lots of protein. So they should arrange their diet reasonably and find a good method to solve this problem from the origin.
Water and solute in blood enter renal capsule via glomerulus to become initial urine, this process must through the endothelial cells , basement membrane of capillary wall and epithelial cells. These three layer structures are called the glomerular filtration membrane. All of the three filtration membranes have certain holes, which only allows the materials that have certain molecular weight and molecular diameter to pass, so they are the size barrier of filtration membranes. The surfaces of three layer structures are covered by silaoprotein, and glomerular basement membrane inside and outside loose layer have rich heparan sulfate, these substances take negative charge in fluid environment, so they reject the solutes that take negative charge to pass, then the charge barrier of filtration membranes forms.
In addition, the intraglomerular mesangium which lies among glomerular capillaries has a regulating action to filtration barrier of glomerulus, so also has a certain effect to the filtration of glomerulus. Under the normal circumstances, most of the protein in blood can not go through the filtration barrier of glomerulus, especially the macromolecules and the albumins that take negative charge almost completely can not go through, a small amount of small molecule proteins which had gotten through filtration can be reabsorbed by kidney tubules, so protein expelled from urine is less than 150mg.
At the time of nephrotic syndrome, barrier function of filtration membrane is destroyed by a variety of pathogenic factors, the holes become bigger and negative charge decreases, which leads to the leakage of a large amount of protein, it outdistance the ability of reabsorption of kidney tubules, so a great quantity of proteinuria appears.
For nephrotic syndrome patients, they also have hypoalbuminemia because of the loss of lots of protein. So they should arrange their diet reasonably and find a good method to solve this problem from the origin.
Say Goodbye to Proteinuria
Nephrotic Syndrome is characterized by the clinical manifestations of high
proteinuria, hyperlipaemia, edema, low albumin. When patients present
proteinuria, they can feel no apparent discomforts. So once the “three high, one
low” manifestations come out, the renal fibrosis has started. If not treated
immediately and reasonably, the Nephrotic Syndrome will develop to renal failure
or uremia, threatening the life eventually.
A lot of patients are very frightened when they know that they are involved in Nephrotic Syndrome, which, to them ,means death. The traditional hormone treatment can remove the proteinuria in a short time, but the disease is very repeated. Hormone can anti-inflammation and remove the proteinuria but cannot repair the injured renal intrinsic cells, let alone blocking the process of renal fibrosis. In this case, the Nephrotic Syndrome treated by hormone is very easy to relapse and each time it relapse, the disease will be more worse. So some Nephrotic Syndrome is still in its early stage, just because misses the best treating opportunity, it can develop to uremia in the end.
The hormone treats the Nephrotic Syndrome only targeting the symptoms rather than the cause, and the cause is the plenty of immune complex deposition, which can recall the disease back once there are some inflammatory factors, either from inside or outside. Then aren’t there any good methods to treat the proteinurtia?
Micro-Chinese Medicine Osmotherapy means that sending the micro-shattered medicine, through Shenshu point, using the intermediate frequency machine to focal areas directly. The medicine has the functions of expanding vessels and improving the micro-circulation in renal partial areas, through which the lack of oxygen and blood in the kidney can be relieved. What’s more it can also degrade some immune complex and difficult-degraded matrix complements. The renal glomerulus can be repaired through its function of promoting blood circulation and removing obstruction in channels, removing stasis and toxins and repairing and restoring, and also, the renal function can recover gradually. Thereby, the proteinuria can vanish completely.
In this case, for the Nephrotic Syndrome patients, we shouldn’t use hormone treatment purely. On the basis of western medicine controlling, disply the micro-Chinese medicine’s great function of repairing renal inherent cells, only by which , can the renal metabolic function recover to its normality. Treating the NS from the root, and get you away from the gloom of proteinuira.
A lot of patients are very frightened when they know that they are involved in Nephrotic Syndrome, which, to them ,means death. The traditional hormone treatment can remove the proteinuria in a short time, but the disease is very repeated. Hormone can anti-inflammation and remove the proteinuria but cannot repair the injured renal intrinsic cells, let alone blocking the process of renal fibrosis. In this case, the Nephrotic Syndrome treated by hormone is very easy to relapse and each time it relapse, the disease will be more worse. So some Nephrotic Syndrome is still in its early stage, just because misses the best treating opportunity, it can develop to uremia in the end.
The hormone treats the Nephrotic Syndrome only targeting the symptoms rather than the cause, and the cause is the plenty of immune complex deposition, which can recall the disease back once there are some inflammatory factors, either from inside or outside. Then aren’t there any good methods to treat the proteinurtia?
Micro-Chinese Medicine Osmotherapy means that sending the micro-shattered medicine, through Shenshu point, using the intermediate frequency machine to focal areas directly. The medicine has the functions of expanding vessels and improving the micro-circulation in renal partial areas, through which the lack of oxygen and blood in the kidney can be relieved. What’s more it can also degrade some immune complex and difficult-degraded matrix complements. The renal glomerulus can be repaired through its function of promoting blood circulation and removing obstruction in channels, removing stasis and toxins and repairing and restoring, and also, the renal function can recover gradually. Thereby, the proteinuria can vanish completely.
In this case, for the Nephrotic Syndrome patients, we shouldn’t use hormone treatment purely. On the basis of western medicine controlling, disply the micro-Chinese medicine’s great function of repairing renal inherent cells, only by which , can the renal metabolic function recover to its normality. Treating the NS from the root, and get you away from the gloom of proteinuira.
Can Repeated Proteinuria Cause Renal Failure
Proteinuria is a early symptom of Chronic Nephritis patients. The change of
proteinuria can affect patients' moods. When "+" decreases, they will be mad
with joy; when "+" increases, they will be sad. The increase of "+" can be
caused by tiredness or influenza, and the increase of proteinuria and its
repetition also can lead to the increase of creatinine. Patients are eager to
know whether the repetition of proteinuria can cause Renal Failure.
Firstly let's see how proteinuria forms. The deposition of lot of immune complex and other substances lead to the glomerular filtration dysfunction and the plasma protein infiltrates into urine, the proteinuria forms. If the immune complex in the kidneys is not eliminated , the proteinuria will appear as soon as patients encounter influenza, tiredness and other external causes. In the treatments of proteinuria, if we don't make clear the internal factors causing disease and just reduce ptoteinuria through drugs, the urine test will turn to negative soon and "+" will decrease. However, the deposited immune complex in kidney becomes more and more and the damage to kidney keeps going on, the final result is the rise of creatinine and Renal Failure occurs.
During the process of worsening of disease, patients can not feel it by themselves. That is because kidneys have strong compensation function. Patients will not feel the obvious discomforts until more than a half of nephrons can not work normally. In general, most of patients will not do punctures, so they have no idea about the degree of deterioration. When proteinuria is being treated repeatedly, unwittingly, Renal Failure comes.
So patients should not ignore the treatments of proteinuria, even though there are no obvious discomforts. But what is important is that finding the right way of treating proteinuria. Micro-Chinese Medicine Osmotherapy is used to make the traditional Chinese medicine penetrates glomerulus basement membrane directly and acts on focus, which can diminish inflammation, sterilize and eliminate the immune complex totally and treat proteinuria from the root.
Firstly let's see how proteinuria forms. The deposition of lot of immune complex and other substances lead to the glomerular filtration dysfunction and the plasma protein infiltrates into urine, the proteinuria forms. If the immune complex in the kidneys is not eliminated , the proteinuria will appear as soon as patients encounter influenza, tiredness and other external causes. In the treatments of proteinuria, if we don't make clear the internal factors causing disease and just reduce ptoteinuria through drugs, the urine test will turn to negative soon and "+" will decrease. However, the deposited immune complex in kidney becomes more and more and the damage to kidney keeps going on, the final result is the rise of creatinine and Renal Failure occurs.
During the process of worsening of disease, patients can not feel it by themselves. That is because kidneys have strong compensation function. Patients will not feel the obvious discomforts until more than a half of nephrons can not work normally. In general, most of patients will not do punctures, so they have no idea about the degree of deterioration. When proteinuria is being treated repeatedly, unwittingly, Renal Failure comes.
So patients should not ignore the treatments of proteinuria, even though there are no obvious discomforts. But what is important is that finding the right way of treating proteinuria. Micro-Chinese Medicine Osmotherapy is used to make the traditional Chinese medicine penetrates glomerulus basement membrane directly and acts on focus, which can diminish inflammation, sterilize and eliminate the immune complex totally and treat proteinuria from the root.
How to Treat Proteinuria of Polycystic Kidney Disease
For polycystic kidney disease patients, proteinuria can be found in their
urine and it shows up as foams and bubbles. But not all the foams and bubbles
are caused by proteinuria. Foams and bubbles which are not caused by proteinuria
can disappear naturally in 24 hours, so patients need not to worry about it. As
to those caused by proteinuria, it means that patients' kidney function has
declined to a certain degree, so patients should receive treatments
promptly.
With the cysts growing continuously, cysts oppress the kidney tissues and damage the glomeruli membrane, causing the increase of permeability of glomeruli membrane. So the protein can be leaked out and enter the urine, foams and bubbles form. Then how to treat proteinuria?
The treatments should not just focus on eliminating proteinuria, we should find out where the problem is. As we mentioned above, the increase of permeability of glomeruli membrane causes the leakage of protein, so the key is to repair the glomeruli membrane, shrink the cysts and recover the renal function.
As to the shrink of cysts, traditional treatments can not treat disease from the root. The small cysts will grow quickly when the big ones are eliminated through operations. When these small cysts grow up, another operation is needed again. The repeated operations can aggravate patients' conditions and delay the treatments.
Micro-Chinese Medicine Osmotherapy aims at stopping kidney fibrosis. After the active materials of Micro-Chinese Medicine Osmotherapy enter the body, they can play the expanding blood vessels, anti-inflammatory, anticoagulation and degradation effects. The active materials have a all-around blocking-up to kidney fibrosis through improving blood-supply of kidney and tissues, eliminating inflammatory response, restraining thrombosis and degrading the extracellular matrixs which deposit abnormally. Also they can provide the essential substances for the recovery of kidney inherent cells, such as vitamins, amino acids and so on. Now we know Micro-Chinese Medicine Osmotherapy treat PKD patients from the root.
With the cysts growing continuously, cysts oppress the kidney tissues and damage the glomeruli membrane, causing the increase of permeability of glomeruli membrane. So the protein can be leaked out and enter the urine, foams and bubbles form. Then how to treat proteinuria?
The treatments should not just focus on eliminating proteinuria, we should find out where the problem is. As we mentioned above, the increase of permeability of glomeruli membrane causes the leakage of protein, so the key is to repair the glomeruli membrane, shrink the cysts and recover the renal function.
As to the shrink of cysts, traditional treatments can not treat disease from the root. The small cysts will grow quickly when the big ones are eliminated through operations. When these small cysts grow up, another operation is needed again. The repeated operations can aggravate patients' conditions and delay the treatments.
Micro-Chinese Medicine Osmotherapy aims at stopping kidney fibrosis. After the active materials of Micro-Chinese Medicine Osmotherapy enter the body, they can play the expanding blood vessels, anti-inflammatory, anticoagulation and degradation effects. The active materials have a all-around blocking-up to kidney fibrosis through improving blood-supply of kidney and tissues, eliminating inflammatory response, restraining thrombosis and degrading the extracellular matrixs which deposit abnormally. Also they can provide the essential substances for the recovery of kidney inherent cells, such as vitamins, amino acids and so on. Now we know Micro-Chinese Medicine Osmotherapy treat PKD patients from the root.
Saturday, October 6, 2012
How to efficiently treat proteinuria for Nephrotic Syndrome patients
Treatments of western medicine mainly use hormone to control proteinuria to make it decreases or turns to be negative in a certain time. This way of treatment can indeed control proteinuria and no lots of leaks. But when patients are attacked by a cold or infected, the urine protein will rise again. So taking medicine over and over again, but no good effects.
Now Micro-Chinese Medicine Osmotherapy has been created, the following information is about the functions of Micro-Chinese Medicine Osmotherapy:
●Micro-Chinese Medicine Osmotherapy could restrain the activity of inflammatory cells and inflammatory mediators, blocking-up the fibrosis and induration of kidney tissues from the point of view of the anti-inflammatory.
●Micro-Chinese Medicine Osmotherapy expands patients' arteries first and increases perfusion of kidney,which can improve the condition of ischemia and anoxia and provide nutrient substances for repairing of damaged parts.
●Micro-Chinese Medicine Osmotherapy could adjust the balance of generating and degradation of extracellular matrix, and degrade extracellular matrix which deposits abnormally in kidney, then proteinuria will get remission. The foams in patients' urine will decrease, the test index of urine protein will be improved, the smell of urine will become strong and precipitate in urine will increase. These changes tell that the degradation of Micro-Chinese medicine is effective.
●Micro-Chinese Medicine Osmotherapy could restrain the forming of microthrombus and improve the blood circulation of damaged parts. Expanding vessels and anti-freezing of Micro-Chinese Medicine Osmotherapy can play the role of redressing ischemia and anoxia.
As long as the kidney function can be improved by Micro-Chinese Medicine Osmotherapy, proteinuria will disappear naturally.
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