Showing posts with label Diabetics. Show all posts
Showing posts with label Diabetics. Show all posts

Monday, June 15, 2015

Treatment Targets for Diabetic Patients on Peritoneal Dialysis

Diabetic patients are often affected by comorbid conditions that influence clinical outcome. Taking care of diabetic peritoneal dialysis (PD) patients is a challenge for nephrologists, not only because these patients have more complications and comorbidities, but also because of their difficulties in maintaining glycemic control with the use of current glucose-containing dialysis solutions.

Diabetes is the most common cause of kidney failure, accounting for nearly 44 percent of new cases. Even when diabetes is controlled, the disease can lead to CKD and kidney failure. Most people with diabetes do not develop CKD that is severe enough to progress to kidney failure. Nearly 24 million people in the United States have diabetes,  and nearly 180,000 people are living with kidney failure as a result of diabetes. People with kidney failure undergo either dialysis, an artificial blood-cleaning process, or transplantation to receive a healthy kidney from a donor. Most U.S. citizens who develop kidney failure are eligible for federally funded care. In 2005, care for patients with kidney failure cost the United States nearly $32 billion.

Diabetes mellitus is the leading cause of end-stage renal disease (ESRD) in many countries. Compared with nondiabetic patients, patients with diabetes generally have poorer survival because of a higher incidence of complications and comorbidities. Strategies for managing diabetic patients on peritoneal dialysis (PD) include proper control of glycemia, ultrafiltration, blood pressure, and metabolic status. In addition, prevention of cardiovascular complications, nutrition optimization, and preservation of residual renal function (RRF) are also important.

Unfortunately, these interventions do not always prevent kidney failure, and approximately 40% of people on dialysis have diabetes as the cause. If a person with diabetes has kidney disease requiring dialysis, the very best option is to get a kidney transplant. However, since getting a transplant usually takes several years and not everyone is able to get one, most people will need to decide between hemodialysis and peritoneal dialysis (PD). In addition to the type of dialysis, a person will choose whether to have dialysis in a dialysis center or perform dialysis at home.

kidneyhospitalabroad@hotmail.com

Monday, May 11, 2015

Further Data on Diabetic Retinopathy Drug Requested

Diabetes is due to either the pancreas not producing enough insulin or the cells of the body not responding properly to the insulin produced. Patients with high blood sugar will typically experience polyuria (frequent urination), they will become increasingly thirsty (polydipsia) and hungry (polyphagia). Prevention and treatment involve a healthy diet, physical exercise, not using tobacco and being a normal body weight.

Eli Lilly and Company has received an approvable letter from the FDA requesting additional supporting data for its new drug application for ruboxistaurin mesylate (proposed trade name: Arxxant), Lilly's investigational oral therapy for diabetic retinopathy.

The company plans to meet with the FDA to determine whether a new study is required to meet the request or if data from an ongoing study will suffice.

“We will be working closely with the FDA to address issues outlined in the approvable letter and to define the pathway forward,” said Timothy R. Franson, MD, the company's vice president of global regulatory affairs.

Last but not least, if kidney damage has been formed by diabetes, the medical treatment should be applied as early as possible. In our Chronic Kidney Disease (CKD) Center, we do use Blood Pollution Therapy to deal with kidney damage. The treatment aims at treating the polluted blood not the kidneys. Under help of various techniques of cleaning blood, the wastes and toxins in blood can be discharged effectively and in the way, the internal environment of the body can be cleaned. Then, some effective reprative medicine and different elements can be supplied.

Sunday, April 26, 2015

Abatacept May Prevent Kidney Disease Advance in Diabetics

Abatacept may help in preventing theprogression of kidney disease in patients with diabetes, according to a study slated for publication in the Journal of the American Society of Nephrology.
Paolo Fiorina, MD, PhD, of Boston Children's Hospital, and colleagues used the drug to target B7-1, a receptor that is expressed by kidney cells during progression to diabetic nephropathy. Abatacept maintained kidney function in mice with diabetic nephropathy.
“The next steps will be to test anti-B7-1 in individuals with diabetes and diabetic nephropathy to see if they can abrogate the progression of the disease in humans as well,” Dr. Fiorina stated.
Abatacept is primarily used to treat autoimmune conditions such as rheumatoid arthritis by targeting receptors expressed in immune cells.

Any questions? Fill the form below. You'll surely get our reply very soon.