High Creatinine Level in Nephrotic Syndrome

For Nephrotic Syndrome patients, they may notice the high creatinine if the condition is not controlled well. The creatinine level will not increase obviously until more than a half of kidney function has been lost. So high creatinine level means severe kidney damage and poor kidney function. Then why can high creatinine happen in Nephrotic Syndrome?

When kidney is violated by all kind of pathogenesis, the damaged kidney inherent cells will get phenotype transformation first, which can form pathological change and stimulate fibroblasts to transform into myofibroblasts, and meanwhile violate and arouse normal kidney tissues to get the same pathological changes, so it has formed a spread process from part to whole and enter the renal damage period. At this moment, because of constant damages of kidney and decrease of function of excreting the wastes, creatinine and other toxins will accumulate in the body, and then high creatinine level appears. Nephrotic Syndrome patients may also get high blood pressure, dropsy and other symptoms.

The appearance of high creatinine also can be explained using inherent cells and extracellular matrix.

All kinds of primary and secondary pathogenesis act on glomerulus continuously for a long time, which can stimulate glomerular local microcirculation barrier and cause the damage of the glomerular capillary endothelial cells. Inflammatory cells in blood circulation will get infiltration and release inflammatory mediators which can cause disease. The progress of kidney fibrosis starts, when mesangial cells are damaged and shrink, the filtration area of glomerulus will declines, meanwhile, the damaged inherent cells will secrete and synthetize a series of ECM that can not be degraded by matrix metalloproteinases (MMP), which stimulates glomerulus induration and renal interstitial fibrosis. A number of creatinine can not be leaked normally but enter blood circulation, which causes high creatinine level.

In order to treat Nephrotic Syndrome from the root, we need to make clear which type of Nephrotic Syndrome patient is suffering. Then the key of High Creatinine Treatment in China should be repairing kidney damage and enhancing kidney function, not lowering high creatinine. After the kidneys regain health and they can work normally again, the creatinine level will go back to the normal level naturally.